Comments on: Health Benefits of Vitamin E http://www.natural-homeremedies.org/blog/health-benefits-of-vitamin-e/ Natural Remedies - Home Remedy Sat, 09 Jul 2011 02:21:41 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: CM Laihttp://www.natural-homeremedies.org/blog/health-benefits-of-vitamin-e/comment-page-1/#comment-80 CM Lai Mon, 29 Jun 2009 07:42:45 +0000 http://www.natural-homeremedies.org/blog/?p=2929#comment-80 Hi there, I came across your post on health benefits of vitamin E and thought that I might add the following points about tocotrienols in preventing heart disease that are not associated with the regular vitamin E tocopherol.Tocotrienols inhibit cholesterol biosynthesis by inhibiting HMG-CoA reductase, the same enzyme inhibited by statins. Both animal and human studies have demonstrated the cholesterol lowering action of tocotrienols. Patients having received 100-200mg of tocotrienols per day for 4-10weeks had a 8-25% LDL-Cholesterol reduction. In contrast, tocopherols do not possess cholesterol lowering activity. Furthermore, high concentration of alpha-tocopherol (above 30% ratio) tend to suppress the cholesterol lowering action of tocotrienols.A double blind placebo controlled human study conducted by researchers at the Kenneth Jordan Heart Foundation showed tocotrienols reverse atherosclerosis in patients with carotid stenosis (narrowing of artery supplying the brain). In this study, daily supplementation of 240mg of palm tocotrienol complex for 6 months led to regression of atherosclerotic plaque and stabilized conditions in 92% of the patients. In contrast, none of the patients receiving placebo showed atherosclerotic regression, instead 40% showed progressive disease. Tocopherols did not show this effect.A recent randomized controlled clinical trial demonstrated that palm tocotrienol complex reduced arterial stiffness in healthy adults after 2 months of oral supplementation. Arterial stiffness is a predictor of cardiovascular events even in healthy individuals. Supplementation from as low as 50mg/day of palm tocotrienol complex (Tocomin SupraBio) for 2 months improves arterial compliance hence reduces the risks of cardiovascular diseases.All the tocotrienol isomers are cardioprotective but the gamma-tocotrienol is the most cardioprotective of all the isomers. In a recent study, researchers at the University of Connecticut School of Medicine found that gamma-tocotrienol has the most potent effect in improving post-ischemic ventricular function and also reducing myocardial infarct size in rats. These researchers concluded that tocotrienols have much higher cardioprotective properties compared to regular alpha-tocopherol vitamin E.References: 1. Qureshi et al. Am J Clin Nutr 1991m 53(S4), 1021S-1026S. 2. Qureshi et al. Lipids 1995, 30(12):1171-7. 3. Qureshi et al. Nutr Biochem 1997,8,290-8. 4. Kooyenga et al. Asia Pac J Clin Nutr 1997,6(1),72-5. 5. Rasool et al. Arch Pharm Res 2008, 31(9),1212-7. 6. Das et al. Am J Physiol Heart Circ Physiol 294:H970-H978, 2008. Hi there, I came across your post on health benefits of vitamin E and thought that I might add the following points about tocotrienols in preventing heart disease that are not associated with the regular vitamin E tocopherol.

Tocotrienols inhibit cholesterol biosynthesis by inhibiting HMG-CoA reductase, the same enzyme inhibited by statins. Both animal and human studies have demonstrated the cholesterol lowering action of tocotrienols. Patients having received 100-200mg of tocotrienols per day for 4-10weeks had a 8-25% LDL-Cholesterol reduction. In contrast, tocopherols do not possess cholesterol lowering activity. Furthermore, high concentration of alpha-tocopherol (above 30% ratio) tend to suppress the cholesterol lowering action of tocotrienols.

A double blind placebo controlled human study conducted by researchers at the Kenneth Jordan Heart Foundation showed tocotrienols reverse atherosclerosis in patients with carotid stenosis (narrowing of artery supplying the brain). In this study, daily supplementation of 240mg of palm tocotrienol complex for 6 months led to regression of atherosclerotic plaque and stabilized conditions in 92% of the patients. In contrast, none of the patients receiving placebo showed atherosclerotic regression, instead 40% showed progressive disease. Tocopherols did not show this effect.

A recent randomized controlled clinical trial demonstrated that palm tocotrienol complex reduced arterial stiffness in healthy adults after 2 months of oral supplementation. Arterial stiffness is a predictor of cardiovascular events even in healthy individuals. Supplementation from as low as 50mg/day of palm tocotrienol complex (Tocomin SupraBio) for 2 months improves arterial compliance hence reduces the risks of cardiovascular diseases.

All the tocotrienol isomers are cardioprotective but the gamma-tocotrienol is the most cardioprotective of all the isomers. In a recent study, researchers at the University of Connecticut School of Medicine found that gamma-tocotrienol has the most potent effect in improving post-ischemic ventricular function and also reducing myocardial infarct size in rats. These researchers concluded that tocotrienols have much higher cardioprotective properties compared to regular alpha-tocopherol vitamin E.

References:
1. Qureshi et al. Am J Clin Nutr 1991m 53(S4), 1021S-1026S.
2. Qureshi et al. Lipids 1995, 30(12):1171-7.
3. Qureshi et al. Nutr Biochem 1997,8,290-8.
4. Kooyenga et al. Asia Pac J Clin Nutr 1997,6(1),72-5.
5. Rasool et al. Arch Pharm Res 2008, 31(9),1212-7.
6. Das et al. Am J Physiol Heart Circ Physiol 294:H970-H978, 2008.

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